Immune Response and Beta Cells

MLA Citation: 

Penn Medicine News. “Penn Study Uncovers How Pancreatic Cells Reprogram Themselves to Limit the Immune Response in Patients at Risk for Type 1 Diabetes - Penn Medicine.” Www.pennmedicine.org, 28 Feb. 2022, www.pennmedicine.org/news/news-releases/2022/february/penn-study-uncovers-how-pancreatic-cells-reprogram-themselves-to-limit-the-immune-response#:~:text=There%20are%20more%20than%2080.

Assessment:

I am currently researching the types of beta cells that can lead to type 1 diabetes. To further my knowledge on this topic, I looked into the article, “Penn Study Uncovers How Pancreatic Cells Reprogram Themselves to Limit the Immune Response in Patients at Risk for Type 1 Diabetes - Penn Medicine.” In this article, it talks a lot about the autoimmune system and there are about 80 different types. However, there was a study where it shows how even if one person has not yet shown symptoms or been clinically diagnosed of diabetes, there have been high levels of the remodeling of one’s beta cells. This is a test to allow doctors so see if people have Type 1 or not. 

This started to make me think, what is the maximum threshold for a person to exceed for the doctors to see if one has diabetes? I wonder this because if there was GAD in one’s cells, then one should be able to detect Type one. However, with the remodeling of the beta cells, has allowed the doctors to not see the GAD levels. It also made me think about at what age this remodeling can happen and if it will go away to then show the GAD levels. The last thing I thought about was how remodeling can affect high levels of GAD. This is because the article talks about the molecular phenotypic changes in the cells of the pancreas being able to show the changes in Type 1 diabetes. 

Some questions that have occurred to me while reading the article would be, how can one figure out the remodeling of the beta cells and the antibody cells. I also wonder if there are different types of remodeling in different type 1 patients. Questions like these also make me wonder if this could also happen with gestational diabetes in pregnant women, and if it does, will it last for a long time or a short time for the pregnant women. Would the remodeling of the beta cells affect the babies in a mother with gestational diabetes? If so, how would it affect the neurological state of both the women and the baby?

I want to research more into the remodeling of the cells, and if that can allow diabetes to change and allow it to refunction if possible. This will allow me to get a better understanding of how the beta cells work and what makes the remodeling of the cells to occur. Whether it be a disruption in the DNA or in the replication process, I want to research if there are different stages and/or conditions of the types of Diabetes. The occurrence of type 1 in different ages is also something I want to look at. This is because I want to see whether the remodeling occurs in different stages and/or different ages. I would also like to research the babies and the pregnant women in finding how and when they are affected with diabetes.